RESUMO Introdução Estudantes universitários representam grande parte dos esportistas amadores na China. Nas práticas esportivas, algumas situações inevitáveis acarretam em lesões físicas que podem afetar seriamente o cotidiano desses alunos. Faz-se necessária a formulação de planos de reabilitação afim de evitar complicações secundárias e agilizar o retorno dos estudantes às suas atividades diárias. Objetivo Estudar as causas de lesões esportivas e o efeito da reabilitação esportiva no treinamento físico universitário. Métodos 720 alunos e 25 professores com histórico de lesão esportiva foram selecionados para investigar as causas de lesão esportiva dos alunos por meio de questionário e entrevista. Em seguida, foram selecionados 20 voluntários como objeto de pesquisa. Esses receberam um protocolo de treinamento em reabilitação três vezes por semana, durante 6 semanas. Foram mensurados os sinais EMG dos músculos do ombro e pescoço dos atletas. Resultados A lesão esportiva é um problema inevitável durante o treinamento físico universitário. Treinar a flexibilidade e estabilidade articular pode efetivamente melhorar os sinais EMG de superfície na área adjacente à articulação, de modo a melhorar a força muscular e o nível de amplitude articular. Conclusão Os alunos devem realizar conscientemente treinamento de reabilitação sob orientação profissional, além de receberem instrução plena sobre os procedimentos da reabilitação esportiva, envolvendo uma combinação de recuperação física e psicológica. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

ABSTRACT Introduction College students represent a large proportion of amateur athletes in China. In sports practices, some unavoidable situations lead to physical injuries that can seriously affect the daily life of these students. Formulating rehabilitation plans to avoid secondary complications and speed up the students’ return to their daily activities is necessary. Objective To study the causes of sports injuries and the effect of sports rehabilitation on university physical training. Methods Through questionnaires and interviews, 720 students and 25 teachers with a history of sports injuries were selected to investigate the causes of students’ sports injuries. Then, 20 volunteers were selected as research subjects. They received a rehabilitation training protocol three times a week for six weeks. EMG signals of the athletes’ shoulder and neck muscles were measured. Results Sports injury is an inevitable problem during college physical training. Training joint flexibility and stability can effectively improve the surface EMG signals in the area adjacent to the joint to improve muscle strength and joint amplitude level. Conclusion Students should consciously undertake rehabilitation training under professional guidance and receive full instruction in sports rehabilitation procedures involving a combination of physical and psychological recovery. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMEN Introducción Los estudiantes universitarios representan una gran parte de los deportistas aficionados en China. En las prácticas deportivas, algunas situaciones inevitables provocan lesiones físicas que pueden afectar gravemente a la vida cotidiana de estos alumnos. Es necesario formular planes de rehabilitación para evitar complicaciones secundarias y acelerar el regreso de los alumnos a sus actividades cotidianas. Objetivo Estudiar las causas de las lesiones deportivas y el efecto de la rehabilitación deportiva en el entrenamiento físico universitario. Métodos Se seleccionaron 720 estudiantes y 25 profesores con antecedentes de lesiones deportivas para investigar las causas de las lesiones deportivas de los estudiantes mediante un cuestionario y una entrevista. A continuación, se seleccionaron 20 voluntarios como sujetos de la investigación. Recibieron un protocolo de entrenamiento de rehabilitación tres veces por semana, durante 6 semanas. Se midieron las señales EMG de los músculos del hombro y del cuello de los atletas. Resultados Las lesiones deportivas son un problema inevitable durante el entrenamiento físico universitario. El entrenamiento de la flexibilidad y la estabilidad articulares pueden mejorar eficazmente las señales EMG superficiales en la zona adyacente a la articulación, de modo que se mejore la fuerza muscular y el nivel de amplitud articular. Conclusión Los estudiantes deben realizar conscientemente un entrenamiento de rehabilitación bajo la dirección de un profesional, y recibir una instrucción completa en los procedimientos de rehabilitación deportiva que impliquen una combinación de recuperación física y psicológica. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Abstract Ficus hirta Vahl chicken soup (FHV+C-S) powder is one of the most popular Chinese-style soup powders due to its high nutritional value and special flavor. In this study, infrared spectroscopy was used to investigate the compatibility between FHV and chicken after decoction, and result showed new absorption peaks (1871 and 1522 cm-1) generated in the mixed soup of FHV-chicken, indicating the interaction between FHV and chicken. The storage stability and shelf life of FHV+C-S powder were also estimated, and results indicated that storage temperature and time greatly influenced the acid value (AV) and peroxide value (POV) of FHV+C-S powder. The regression equations of FHV+C-S powder simulated by the first-order kinetic equation and the Arrhenius equation showed a high fit coefficient (R2 > 0.9), and the shelf-life of the powder was predicted to be 568 days. Gas chromatography-ion mobility spectrometry (GC-IMS) was employed to analyze the changes in volatile compounds in FHV+C-S powder during storage, and results indicated the fluctuation of flavor compounds, with some decreased with storage time prolonged, such as 2-phenylethanol, hexanal, butanone, butyraldehyde, while some other increased, such as amyl alcohol, valeraldehyde, 2-octanone, 2-heptanone. This demonstrated GC-IMS as a visualized tool for flavor compounds and stability analysis.

RESUMO Introdução A técnica no arremesso de peso e a habilidade na etapa de arremessar são dois fatores importantes que determinam a habilidade dos atletas Especialistas e treinadores qualificados atribuem grande importância ao treinamento e pesquisa sobre a habilidade da fase de arremesso e a capacidade de arremessar. Objetivo Comparar o treinamento com carga gravitacional e o treinamento com carga incremental única através de meios experimentais, analisando os impactos na habilidade de arremesso nos atletas. Métodos O método de auto-avaliação foi usado para realizar o experimento comparativo de diferentes formas de treinamento de força em 20 estudantes universitários. O esquema experimental adota o treinamento único de força de carga incremental, e o esquema de controle adota o treinamento tradicional de barra. Resultados : Após o experimento, o ângulo da mão do grupo I foi significativamente maior do que o do grupo II (P < 0,05); após o experimento, o ângulo do ombro do grupo I foi significativamente maior do que o do grupo II (P < 0,05); após o experimento, o desempenho do tiro sentado colocado no grupo I foi significativamente maior do que o do grupo II (P < 0,05), e não houve diferença significativa no desempenho em pé (P > 0,05). Conclusão O treinamento com carga incremental única pode melhorar significativamente a capacidade de arremesso dos atletas de arremesso de peso. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

ABSTRACT Introduction The technique in the shot put and the ability in the throwing stage are two important factors that determine the ability of athletes. Qualified experts and coaches attach great importance to training and research on the ability of the throwing stage and the ability to throw. Objective Compare gravity load training and single incremental load training through practical means, analyzing the impacts on throwing ability in athletes. Methods The self-assessment method was used to conduct the comparative experiment on different forms of strength training in 20 college students. The experimental scheme adopts the single incremental load strength training, and the control scheme adopts the traditional barbell training. Results : After the experiment, the hand angle of group I was significantly higher than that of group II (P < 0.05); after the experiment, the shoulder angle of group I was significantly higher than that of group II (P < 0.05); after the experiment, the performance of the seated shot placed in group I was significantly higher than that of group II (P < 0.05), and there was no significant difference in the standing performance (P > 0.05). Conclusion Single incremental load training can significantly improve the throwing ability of shot put athletes. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMEN Introducción La técnica en el lanzamiento de peso y la habilidad en la fase de lanzamiento son dos factores importantes que determinan la habilidad de los atletas. Los especialistas y entrenadores cualificados atribuyen gran importancia a la formación y a la investigación sobre la habilidad de la fase de lanzamiento y la habilidad de lanzamiento. Objetivo Comparar el entrenamiento con carga gravitacional y el entrenamiento con carga incremental única a través de medios experimentales, analizando los impactos en la capacidad de lanzamiento en los atletas. Métodos Se utilizó el método de autoevaluación para realizar el experimento comparativo de diferentes formas de entrenamiento de fuerza en 20 estudiantes universitarios. El esquema experimental adopta el entrenamiento de fuerza con una sola carga incremental, y el esquema de control adopta el entrenamiento tradicional con barra. Resultados : Después del experimento, el ángulo de la mano del grupo I fue significativamente mayor que el del grupo II (P < 0,05); después del experimento, el ángulo del hombro del grupo I fue significativamente mayor que el del grupo II (P < 0,05); después del experimento, el rendimiento del lanzamiento de peso sentado del grupo I fue significativamente mayor que el del grupo II (P < 0,05), y no hubo diferencias significativas en el rendimiento de pie (P > 0,05). Conclusión El entrenamiento con una sola carga incremental puede mejorar significativamente la capacidad de lanzamiento de los atletas de lanzamiento de peso. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

ABSTRACT Introduction: Shot put is a competitive sport that combines speed, strength, and explosiveness. Training the skill with aerobic exercise has attracted the attention of many coaches and scholars on competitive sports training. Shot put is a fast-powered activity, and its shooting speed is the determining factor for sports performance. It is believed that aerobic exercise can improve the ability of its practitioners. Objective: To analyze the impacts of aerobic exercise on the physical fitness of shot put athletes. Methods: 18 shot put athletes were randomly selected as volunteers for research that consisted of a random division between experimental and control groups. The experimental group received a protocol involving aerobic training, while the control group received regular training before, during, and after the experiment. The maximal strength and explosive power of the two groups of athletes were tested before and after the intervention, and mathematical-statistical methods were used to process the collected data. Results: The maximum strength index of both groups was improved; however, the improvement in the experimental group was statistically relevant(P<0.05). The values of the pressure index, power, and balance of the athletes from the experimental group were statistically altered to those before the experiment (P<0.01). Conclusion: The implementation of aerobic exercise in the routine of shot put athletes can effectively improve the performance in the sport and the special abilities of its practitioners. The training method analyzed was also shown to improve specific performance in the shot put athletes. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

Resumen Introducción: El lanzamiento es un deporte de competición que combina velocidad, fuerza y explosividad. El entrenamiento de la capacidad con ejercicios aeróbicos ha atraído la atención de muchos entrenadores y estudiosos del entrenamiento deportivo de competición. El lanzamiento es una actividad de potencia rápida, y su velocidad de tiro es el factor determinante para el rendimiento deportivo. Se cree que el ejercicio aeróbico puede mejorar la capacidad de sus practicantes. Objetivo: Analizar los impactos del ejercicio aeróbico en la condición física de los atletas de lanzamiento. Métodos: Se seleccionaron aleatoriamente 18 practicantes de lanzamiento como voluntarios para una investigación que consistió en la división aleatoria entre los grupos experimental y de control. El grupo experimental recibió un protocolo de entrenamiento aeróbico, mientras que el grupo de control recibió su entrenamiento habitual antes, durante y después del experimento. Se comprobó la fuerza máxima y la potencia explosiva de los dos grupos de atletas antes y después de la intervención, y se utilizaron métodos estadísticos matemáticos para procesar los datos recogidos. Resultados: El índice de fuerza máxima de ambos grupos mejoró, aunque la mejora en el grupo experimental fue estadísticamente relevante (P<0,05). Los valores del índice de presión, la potencia y el equilibrio de los atletas del grupo experimental estaban estadísticamente alterados en relación con los anteriores al experimento (P<0,01). Conclusión: La implementación del ejercicio aeróbico en la rutina de los atletas de lanzamiento puede mejorar efectivamente el rendimiento en el deporte y las habilidades especiales de sus practicantes. El método de entrenamiento analizado también ha demostrado mejorar el rendimiento específico de los atletas de lanzamiento. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

RESUMO Introdução: O arremesso é um esporte de competição que combina velocidade, força e explosividade. O treinamento da capacidade com exercício aeróbico atraiu a atenção de muitos treinadores e estudiosos sobre treinamento esportivo de competição. O arremesso é uma atividade de potência rápida, e sua velocidade de tiro é o fator determinante para o desempenho esportivo. Acredita-se que o exercício aeróbico possa melhorar a habilidade de seus praticantes. Objetivo: Analisar os impactos do exercício aeróbico na aptidão física dos atletas de arremesso. Métodos: 18 praticantes de arremesso foram selecionados aleatoriamente como voluntários para uma pesquisa que consistiu na divisão aleatória entre grupos experimental e de controle. O grupo experimental recebeu um protocolo envolvendo o treinamento aeróbico, enquanto o grupo de controle recebeu seu treinamento regular antes, durante e depois do experimento. A força máxima e o poder explosivo dos dois grupos de atletas foram testados antes e após a intervenção, foram usados métodos estatísticos matemáticos para processar os dados coletados. Resultados: O índice de força máxima dos dois grupos foi aprimorado, porém a melhoria no grupo experimental foi estatisticamente relevante(P<0,05). Os valores do índice de pressão, potência e balanço dos atletas do grupo experimental foram estatisticamente alterados em relação aqueles anteriores ao experimento (P<0,01). Conclusão: A implementação do exercício aeróbico na rotina dos atletas de arremesso pode efetivamente melhorar o desempenho no esporte e as habilidades especiais dos seus praticantes. O método de treinamento analisado também demonstrou melhorar o desempenho específico nos esportistas de arremesso. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

ABSTRACT Introduction: This study summarizes the clinical data of patients who developed sternotomy hemorrhage during redo aortic surgery and analyzes the clinical experience of using hypothermic circulatory arrest. Methods: We retrospectively analyzed the medical records of patients who developed sternotomy hemorrhage during redo aortic surgery from May 2018 to August 2021. General anesthesia with single-lumen tracheal intubation was used. Femoral artery, vein, and superior vena cava cannulation were used if cardiopulmonary bypass was required according to the situation, and right superior vein or apical cannulation was selected for left heart drainage. Results: A total of 11 patients were enrolled in this study, comprising nine males and two females, with an average age of 44.3±16.7 years. All cases were successfully completed without cerebrovascular complications or paraplegia. Two patients died during hospitalization, two patients died during the follow-up after discharge, and the remaining patients are recovering well. Conclusion: The femoral-femoral bypass with hypothermic circulatory arrest technique is a safe and reliable method to use in cases of sternotomy hemorrhage during redo aortic surgery.

Resumo Objetivo Os produtos financeiros estruturados (SPs) tornaram-se muito populares entre os investidores de varejo nos últimos anos. A preferência dos investidores desempenha um papel crítico para investir em SPs. O objetivo deste estudo é entender o comportamento de investimento nos SPs investigando as preferências heterogêneas dos investidores chineses para a escolha de WMPs com determinados atributos. Referencial teórico Os investidores com diferentes características demográficas apresentam diferentes preferências em seus investimentos em SPs. Metodologia Empregamos o método de experimentos de escolha (CE) e examinamos a heterogeneidade de preferência usando os modelos logit multinomial (MNL) e logit misto (MXL). Resultados (i) Os atributos “banco pequeno”, “valor mínimo”, “retorno variável não garantido” e “retorno variável garantido” afetam significativamente a escolha de compra dos WMPs. (ii) Existem preferências heterogêneas significativas por valor mínimo. (iii) Esses quatro elementos são as fontes de preferência heterogênea por valor mínimo. Implicações práticas e sociais da pesquisa A pesquisa oferece informações que podem contribuir para a compreensão das preferências heterogêneas das características dos investidores, o que pode ajudar a desenvolver WMPs comercializáveis para atingir diferentes tipos de investidores. Contribuições A principal contribuição da pesquisa é examinar as preferências heterogêneas dos investidores por SPs. O estudo fornece evidências empíricas de quais atributos de produtos estruturados afetam significativamente as preferências dos investidores. Também revela quais características dos investidores afetam suas preferências heterogêneas.

Abstract Purpose Structured financial products (SPs) have become very popular with retail investors in recent years. Investors’ preferences play a critical role when investing in SPs. The objective of this study is to understand SP investment behavior by investigating Chinese investors’ heterogeneous preferences for choosing wealth management products (WMPs) with certain attributes. Theoretical framework Investors with different demographic characteristics show different preferences in their SP investments. Design/methodology/approach We employ the choice experiment (CE) method and examine preference heterogeneity using the multinomial logit (MNL) and the mixed logit (MXL) models. Findings (i) The attributes of small bank, minimum amount, non-guaranteed floating return and guaranteed floating return significantly affect the choice when purchasing WMPs. (ii) There are significant heterogeneous preferences for minimum amount. (iii) These four characters are the sources of heterogeneous preferences for minimum amount. Practical & social implications of research This information can contribute to understanding the heterogeneous preferences of investors, which can help in designing marketable WMPs to target different kinds of investors. Originality/value The main contribution of the research is it examines investors’ heterogeneous preferences for SPs. The study provides empirical evidence of which attributes of structured products significantly affect investor preferences. It also reveals which characteristics of investors affect their heterogeneous preferences.

SUMMARY OBJECTIVE: A growing volume of literature has suggested long noncoding RNAs (lncRNAs) as important players in tumor progression. In this study, we aimed to investigate the expression and prognostic value of lncRNA LINC00173 (LINC00173) in melanoma. METHODS: LINC00173 expression was measured in 163 paired cancerous and noncancerous specimen samples by real-time polymerase chain reaction. The correlations between LINC00173 expression with clinicopathological characteristics and prognosis were analyzed by chi-square test, log-rank test, and multivariate survival analysis. Receiver-operating characteristic curves were used for the assessment of the diagnostic value of LINC00173 for melanoma patients. RESULTS: The expression level of LINC00173 in melanoma specimens was distinctly higher than that in adjacent non-neoplasm specimens (p<0.01). Besides, LINC00173 was expressed more frequently in patients with advanced melanoma than in patients with early melanoma. Multivariate assays confirmed that LINC00173 expression level was an independent prognostic predictor of melanoma patients (p<0.05). CONCLUSION: Our data indicated that LINC00173 expression could serve as an unfavorable prognostic biomarker for melanoma patients.

Abstract Severe lactic acidosis, a mitochondrial toxicity caused by the recommended standard dosage of linezolid (LZD), may occur in patients with impaired renal function. We describe an adult male who underwent kidney transplantation with stably impaired renal function, severe dyspnea, and abdominal discomfort. He received a standard oral dose of LZD (600 mg twice daily) and azithromycin for three weeks with a reduced immunosuppressant dose due to pulmonary non-tuberculosis mycobacterial infection. He was alert and afebrile, with a blood pressure of 140/60 mmHg. Pertinent laboratory data showed: pH 7.12, PaCO2 13.6 mmHg; HCO3- 4.3 mmol/L and serum lactate 18.4 mmol/L. His trough serum LZD concentration reached toxic levels (21.4 μg/mL). With hemodialysis, his clinical symptoms improved, with a decline in serum LZD (9.8μg/mL) and lactate (3.2 mmol/L). Chronic standard dose LZD in patients with impaired renal function can lead to life-threatening lactic acidosis, especially in coexisting conditions that reduce LZD metabolism.

Abstract The aim of this study was to investigate the influence of microwave drying on the protein quality of japonica sorghum following an intermittent drying test. Using label-free technology and liquid chromatography-tandem mass spectrometry for proteomic analysis, the effects of microwave drying on sorghum differential protein expression, functional classification, and metabolic pathways were analyzed at the molecular level. After sorghum was dried using a microwave, 85 differential proteins were identified. Among them, 51 showed up-regulated expression while 34 had down-regulated expression. The up-regulation and down-regulation of differential protein expressions significantly changed them, and proteins with larger up-regulated and down-regulated expressions were postulated to affect biological and metabolic processes of sorghum during subsequent processing. Differential proteins were significantly (P ˂ 0.01) involved in metabolic pathways, such as carbon metabolism, glycolysis/gluconeogenesis, carbon fixation in photosynthetic organisms, biosynthesis of amino acids, amino sugar and nucleotide sugar metabolism, and the TCA cycle. For the protein interaction network, glyceraldehyde-3-phosphate dehydrogenase of the down-regulated proteins was postulated to be the key factor affecting the entire metabolic system or signal transduction pathway. Up-regulated proteins, including phosphoglycerate mutase and phosphopyruvate hydratase, as well as down-regulated proteins such as glyceraldehyde-3-phosphate dehydrogenase and fructose-bisphosphate aldolase, not only directly or indirectly affected a variety of metabolic processes, but were specifically closely related to glycolysis and glycometabolism. Overall, this study showed that among the related metabolic pathways, differential protein changes in glycometabolism pathways may have the greatest impact on metabolic processes. The research results discussed herein can provide theoretical support for the industrial application of microwave drying and deep processing of sorghum.

ABSTRACT To accurately measure sowing depth, we designed a multisensor data fusion algorithm based on the Kalman filter and applied it to a dual-channel ultrasonic sowing depth measurement system. We installed two ultrasonic sensors on the frame above the depth limit wheel and the soil covering-compacting wheel. The terrain-like plate was installed on the central axis of the depth limit wheel to simulate the surface relief and calculate the seeding depth value. The Kalman filter algorithm filters out the clutter generated when the two ultrasonic sensors collect the depth data and then fuses the two ultrasounds of the filtered data. The test shows that when the vehicle speed is 4 km/h , the fluctuation ranges of the collected data of ultrasonic 1 and 2 are 45-60 mm and 35-70 mm , respectively, and the fluctuation ranges of the filtered data are 52-58 mm and 48-60 mm , respectively. After data fusion processing, the data fluctuate in a small range of approximately 55 mm . When the vehicle speed is 6 km/h and 8 km/h, the obtained results have the same trend as the experimental results at 4 km/h . The results show that the sowing depth measurement system is effective.

ABSTRACT Recent research has shown that genetic variations in the oxytocin receptor (OXTR) may be related to variations in subtypes of obsessive-compulsive disorder (OCD). We aimed to explore the relationship between different subtypes of OCD and the genetic variation between rs1316193 and rs4686301 of the OXTR. In this case-control study, 92 OCD patients and 92 healthy controls were included in the OCD and control groups, respectively. The Y-BOCS scale was used to assess the severity of the OCD symptoms. The fasting peripheral blood samples were collected to extract DNA. rs4686301 and rs13316193 were genotyped using restriction fragment length polymorphism analysis techniques. Whether the gene frequency of the locus and the distribution of allele frequency were related to OCD were further study by TaqMan allele typing. The rs4686301 locus differed significantly between behavior and control groups. The genotype frequency and allele frequency at the rs4686301 locus were statistically significant between behavior and control groups (P<0.05). There was significant difference in the genotype frequency at the rs13316193 locus between behavior and control groups (P<0.05). The rs4686301 polymorphism of the OXTR may affect the clinical subtype of OCD. The rs13316193 polymorphism of the OXTR may be a risk factor for obsessive-compulsive behavior.

Abstract Background Unhealthy teeth can seriously affect general health and increase the risk of death in elderly people. There has been no confirmation of which device is most effective for elderly patients with teeth loss. Therefore, we compared four intubation devices in elderly patients with partial and total tooth loss aiming to reduce risk during anesthesia. Methods Two hundred patients were randomized to undergo tracheal intubation with the Macintosh laryngoscope, the Glidescope, the Fiberoptic bronchoscope or the Lightwand as part of general anesthesia. A unified protocol of anesthetic medications was used. HR and BP were measured at T0, T1, T2, T3, T4 and T5. Catecholamine (epinephrine and norepinephrine) blood samples were drawn at T0, T1 and T2. Intubation time and postoperative complications, including dental damage and losses, were recorded. Results Reduced fluctuations in HR, DBP, and SBP were observed in the Lightwand group. Intubation time was significantly shorter in the Lightwand group (p < 0.05). There was no statistically significant difference between the groups in epinephrine levels, but norepinephrine levels were less volatile in the Fiberoptic bronchoscope and Lightwand groups. Fewer patients in the Lightwand group experienced dental damage and other postoperative complications than in the other three groups. Although a higher success rate on the first attempt was as high as in the Fiberoptic bronchoscope group, shorter intubation time was observed only in the Lightwand group. Conclusion The Lightwand offers less hemodynamic stimulation than the Macintosh laryngoscope, Glidescope, and Fiberoptic bronchoscope. Because it had the shortest intubation time, the Lightwand caused the least damage to the teeth and throat of elderly patients. Our findings showed that tracheal intubation with the Lightwand was advantageous for preventing cardiovascular stress responses with short intubation times and fewer postoperative complications.

RESUMO É particularmente importante melhorar a qualidade dos programas de educação física e o nível geral de saúde dos estudantes universitários. É difícil obter uma avaliação abrangente do método de avaliação inicial do nível de saúde física dos estudantes. Por conseguinte, este estudo combinou o processo hierárquico analítico (AHP) e o modo de condicionamento físico para construir um modelo universitário de avaliação da saúde física. Tendo a Universidade X como objeto experimental, vinte estudantes de diferentes especializações do período de 2019 foram selecionados como objetos experimentais. Um grupo ( de dez estudantes) adotou o modo de educação física original, e o outro grupo (de dez estudantes) integrou o condicionamento físico no currículo de educação física. Utilizando o modelo estabelecido de avaliação da saúde, as pontuações de avaliação do nível de saúde física de dois grupos de estudantes universitários antes e depois do experimento foram exaustivamente analisadas. Os resultados mostraram que a pontuação global do nível de saúde física de um grupo de estudantes aumentou. A taxa de aumento foi de 2.87%. No entanto, não houve alterações significativas nas pontuações da avaliação para a saúde física dos estudantes do grupo B. Os resultados mostram que o condicionamento físico no currículo público de educação física pode contribuir efetivamente para melhorar o nível geral de saúde dos estudantes, e também mostra que a introdução do processo hierárquico analítico (AHP) na avaliação do nível de saúde física dos estudantes universitários pode melhorar a abrangência da análise do nível de saúde. Espera-se que este estudo possa fornecer uma referência para o ensino de educação física nos colégios e universidades a fim de melhorar o nível de ensino geral das universidades.

ABSTRACT It is particularly important to improve the quality of physical education curriculum and the overall health level of college students. It is difficult to achieve a comprehensive evaluation of the original evaluation method of students' physical health level. Therefore, this study combined the analytic hierarchy process (AHP) and physical fitness training mode to build a university physical health evaluation model. Taking X University as the experimental background, 20 students of different majors in grade 2019 were selected as experimental objects. One group (10 students) adopted the original physical education curriculum mode, and the other group (10 students) integrated physical fitness training into the physical education curriculum. Using the established health evaluation model, the evaluation scores of physical health level of two groups of college students before and after the experiment were comprehensively analyzed. The results showed that the overall score of group A students' physical health level increased; the rising rate was 2.87%. However, there was no significant change in the scores of physical health assessment of group B students. The results show that physical fitness training into the public physical education curriculum can effectively help improve the overall health level of students, and also shows that the introduction of AHP into the evaluation of College Students' physical health level can improve the comprehensiveness of health level analysis. It is hoped that this study can provide some reference for physical education teaching in Colleges and universities, so as to improve the overall teaching level of colleges and universities.

RESUMEN Es particularmente importante mejorar la calidad del plan de estudios de educación física y el nivel de salud general de los estudiantes universitarios. Es difícil lograr un análisis integral del método de evaluación original del nivel de salud física de los estudiantes. Por lo tanto, este estudio combinó el proceso de jerarquía analítica (PJA) y el modo de entrenamiento de aptitud física para construir un modelo universitario de evaluación de la salud física. Tomando la Universidad X como base experimental, se seleccionaron como sujetos experimentales 20 estudiantes de diferentes carreras en los cursos de 2019. Un grupo (10 estudiantes) adoptó el modo de plan de estudios de educación física original y el otro grupo (10 estudiantes) integró el entrenamiento de aptitud física en el plan de estudios de educación física. Utilizando el modelo de evaluación de salud establecido, se analizaron exhaustivamente los puntajes de evaluación del nivel de salud física de los dos grupos de estudiantes universitarios antes y después del experimento. Los resultados mostraron que el puntaje general del nivel de salud física de los estudiantes del grupo A aumentó; la tasa de incremento fue del 2,87%. Sin embargo, no hubo cambios significativos en las puntuaciones de la evaluación de la salud física de los estudiantes del grupo B. Los resultados muestran que el entrenamiento de la aptitud física en el plan de estudios público de educación física puede ayudar de manera efectiva a mejorar el nivel de salud general de los estudiantes y también muestra que la introducción de PJA en la evaluación del nivel de salud física de los estudiantes universitarios puede mejorar la precisión del análisis del nivel de salud. Esperamos que este estudio pueda proporcionar una referencia para la enseñanza de la educación física en los colegios y universidades, a fin de mejorar su nivel general en estos establecimientos.

The objective of this study was to investigate the effect of Mycobacterium vaccae on Jagged 1 and gamma delta T17 (γδT17) cells in asthmatic mice. An asthma mouse model was established through immunization with ovalbumin (OVA). Gamma-secretase inhibitor (DAPT) was used to block the Notch signaling pathway. M. vaccae was used to treat asthma, and related indicators were measured. Blocking Notch signaling inhibited the production of γδT17 cells and secretion of cytokine interleukin (IL)-17, which was accompanied by a decrease in Jagged1 mRNA and protein expression in the treated asthma group compared with the untreated asthma group. Similarly, treatment with M. vaccae inhibited Jagged1 expression and γδT17 cell production, which was associated with decreased airway inflammation and reactivity. The Notch signaling pathway may play a role in the pathogenesis of asthma through the induction of Jagged1 receptor. On the other hand, the inhibitory effect of M. vaccae on Jagged1 receptor in γδT17 cells could be used for the prevention and treatment of asthma.

Abstract Klebsiella pneumoniae is important human and animal pathogen that causes a wide spectrum of infections. In this study, isolates from cattle nasal swabs samples were identified by 16S rRNA, and to evaluate the antimicrobial susceptibility, virulence gene carrying levels, and multilocus sequence typing of K. pneumoniae isolates. 33 isolates of K. pneumoniae were isolated and identified in 213 nasal swabs samples, of which 12 were hypervirulent K. pneumoniae strains. Extended Spectrum Beta-Lactamases genes were found in 93.4% of the strains. Of which, TEM was the most prevalent (93.4%), followed by CTX-M and SHV were 57.6% and 39.4%, respectively. A main mutation pattern of quinoloneresistance-determining region, Thr83-Ieu and Asp87-Asn in gyrA and Ser87-Ile in parC, was detected in 33 K. pneumoniae isolates. All the isolates harbored at least two virulence factor genes, with ureA (97.0%) and wabG (91.0%) exhibiting high carriage rates in 33 K. pneumoniae isolates. MLST revealed 7 sequence types, of which 3 STs (2541, 2581 and 2844) were newly assigned. Using eBURST, ST2844 and ST2541 were assigned to new clonal complex 2844. Our study provides evidence and biological characteristics of K. pneumoniae isolates from cattle upper respiratory tract in Southwest China.